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Kathya D. Díaz-García 1, Anahí García-Soria 1, Mireya Alcaraz-Zubeldia 2, Rigoberto González-Piña 3, 4, 5, Laura E. Ramos-Languren 1, 4
1 Division of Professional Studies, Faculty of Psychology, Universidad Nacional Autonoma de Mexico, Mexico City, Mexico; 2 Department of Neurochemistry, Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez, SSA, Mexico City, Mexico; 3 Section of Graduate Studies and Research, School of Medicine, Instituta Politecnico Nacional, Mexico City, Mexico; 4 Brain Injury Rehabilitation Clinic CLIREDACE “Dr. Hugo Iván González Gutiérrez”, Mexico City, Mexico; 5 Department of Special Education, Universidad de las Americas, Mexico City, Mexico
Kathya D. Díaz-García, Anahí García-Soria, Mireya Alcaraz-Zubeldia, Rigoberto González-Piña, Laura E. Ramos-Languren
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*Correspondence: Laura E. Ramos-Languren. Email: elanguren@comunidad.unam.mx
Objective: Stroke is a leading cause of death and disability worldwide, often resulting in post-stroke depression (PSD), a common neuropsychiatric consequence affecting survivors’ quality of life. This study aimed to determine whether the photothrombotic lesion technique is a suitable model for studying PSD. Methods: The photothrombotic lesion method could effectively induce a depression-like phenotype in rats, facilitating the study of PSD without causing significant motor deficits. An ischemic lesion was induced in the left medial prefrontal cortex of 43 male Wistar rats. Depression-like behavior was assessed using the sucrose preference test and the forced swim test (FST) at 14- and 30-days post-stroke (DPS), respectively. The beam walking test (BWT) was used to evaluate motor function at 30 DPS. Results: Stroke rats showed reduced sucrose preference at 14 DPS, indicating anhedonia. However, no significant differences were observed in the FST or BWT at 30 days. Conclusions: The photothrombotic lesion model showed potential for studying PSD, but the behavioral results were inconclusive. Future research should include depression biomarkers to better assess the model’s validity.
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