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Association of Toll-like receptor 2, Toll-like receptor 4, and MyD88 gene polymorphisms with inflammation in subjects with metabolically healthy obesity
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- Published: October 1, 2026
Association of Toll-like receptor 2, Toll-like receptor 4, and MyD88 gene polymorphisms with inflammation in subjects with metabolically healthy obesity
Fernando Guerrero-Romero 1, Claudia I. Gamboa-Gómez 1, Francisco X. Castellanos-Juaréz 2, Jose M. Salas-Pacheco 2, Francisco G. Morales-Gurrola 1, 2, Alma C. Salas-Leal 2, Luis E. Simental-Mendía 3 
1 Biomedical Research Unit, Delegación Durango, Instituto Mexicano del Seguro Social, Durango, Mexico; 2 Institute of Scientific Research, Universidad Juárez del Estado de Durango, Durango, Mexico; 3 Unidad de Investigación Biomédica, Delegación Durango, Instituto Mexicano del Seguro Social, Durango, Durango, México
Fernando Guerrero-Romero, Claudia I. Gamboa-Gómez, Francisco X. Castellanos-Juaréz, Jose M. Salas-Pacheco, Francisco G. Morales-Gurrola, Alma C. Salas-Leal, Luis E. Simental-Mendía
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*Correspondence: Luis E. Simental-Mendía. Email: luis_simental81@hotmail.com
Abstract
Objectives: The aim of this study was to determine the association between the polymorphisms of Toll-like receptors (TLR2), TLR4, and MyD88 with inflammation in individuals with metabolically healthy obesity (MHO). Methods: Men and non-pregnant women with obesity were included in a cross-sectional study. Then, subjects diagnosed with MHO were allocated into the groups with and without inflammation. Low-grade inflammation was defined by C-reactive protein concentrations ≥ 3 < 10 g/dL. Results: A total of 64 subjects with MHO were enrolled and allocated into the groups with (n = 37) and without (n = 27) inflammation. The distribution of alleles and genotypes were not significantly different for the TLR4 rs11536889, TLR2 rs380499, and MyD88 rs7744 polymorphisms between the study groups. However, the genotypes G/A and G/A + A/A of the TLR4 rs10759931 polymorphism were significantly associated with inflammation. Conclusions: The TLR4 rs10759931 polymorphism, but not TLR4 rs11536889, TLR2 rs3804099, and MyD88 rs7744, is associated with low-grade inflammation in MHO.
Keywords: Obesity. Inflammation. Toll-like receptors. MyD88. Genetics.
