Importance and use of corneal biomechanics and its diagnostic utility




Arturo Ramirez-Miranda, Departamento de Córnea y Cirugía Refractiva, Instituto de Oftalmología Fundación Conde de Valenciana, Ciudad de México, México
Simran Mangwani-Mordani, Departamento de Córnea y Cirugía Refractiva, Instituto de Oftalmología Fundación Conde de Valenciana, Ciudad de México, México
José Y. Arteaga-Rivera, Departamento de Córnea y Cirugía Refractiva, Instituto de Oftalmología Fundación Conde de Valenciana, Ciudad de México, México
Renato Ambrosio Jr., Brazilian Study Group of Artificial Intelligence and Corneal Analysis - BrAIN, Rio de Janeiro & Maceió, Brazil
Alejandro Navas, Departamento de Córnea y Cirugía Refractiva, Instituto de Oftalmología Fundación Conde de Valenciana, Ciudad de México, México
Enrique O. Graue-Hernandez, Departamento de Córnea y Cirugía Refractiva, Instituto de Oftalmología Fundación Conde de Valenciana, Ciudad de México, México
Jorge E. Valdez-García, Escuela de Medicina y Ciencias de la Salud, Instituto de Oftalmología y Ciencias Visuales, Tecnológico de Monterrey, Monterrey, Nuevo León, México


The study of corneal biomechanics has become relevant in recent years due to its possible applications in the diagnosis, management, and treatment of various diseases such as glaucoma, keratorefractive surgery and different corneal diseases. The clinical biomechanical investigation has become of great importance in the setting of refractive surgery to identify patients at higher risk of developing iatrogenic ectasia. This review focuses on two of the technologies available for clinical use, the Ocular Response Analyzer (Reichert Ophthalmic Instruments, Buffalo, NY, USA) and the Corvis ST (Oculus Optikgergäte GmbH, Wetzlar, Germany). Both are non-contact tonometers that provided a clinical evaluation of corneal biomechanics. The fundamentals and main parameters of each device are described, as well as their use in eye surgery and the corneal biomechanical behavior in eye diseases. Finally, we will discuss the more recent Brillouin microscopy biomechanical analysis, and the integration Scheimpflug-based corneal tomography and biomechanical data with artificial intelligence to increase accuracy to detect risk of ectasia.



Keywords: Dynamic bidirectional applanation tonometry. Contactless Scheimpflug tonometry. Corneal biomechanics.