Zambia Koukouritaki, Department of Surgery, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece Ioannis Mantzoros, Department of Surgery, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece Orestis Ioannidis , Department of Surgery, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece Styliani Parpoudi, Department of Surgery, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece Konstantinos Galanos-Demiris, Department of Surgery, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece Panagiotis Christidis, Department of Surgery, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece Manousos G. Pramateftakis, Department of Surgery, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece Efstathios Kotidis, Department of Surgery, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece Nikolaos Ouzounidis, Department of Surgery, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece Charalambos Dimitriadis, Department of Surgery, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece Stamatios Angelopoulos, Department of Surgery, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece


Aim: The purpose of the study was to evaluate the effect of oral administration of n-3 polyunsaturated fatty acids in experimental ischemic enteritis in rats. Methods: Forty Wistar rats were submitted to control narrowing of the superior mesenteric artery and were divided in two groups: N3 polyunsaturated fatty acids, which received a high-molecular polymer solution of artificial total enteral nutrition enriched with n-3 fatty acids and CONTROL which received a high-molecular polymer solution of artificial total enteral nutrition. Results: Reduction of the animals’ body weight was observed in both groups, but there was no difference between the two groups. Regarding the level of cytokines interleukin (IL)-1b, IL-6, and tumor necrosis factor a (TNF-a) there was no statistically significant difference between the two groups. Ischemic lesions to the small bowel mucosa were observed in both groups. A statistically significant difference in the extent of intestinal lesions was observed between the two groups with the animals that received enteral nutrition enriched with n-3 fatty acid developing fewer lesions. Conclusion: Enteral nutrition enriched with n-3 polyunsaturated fatty acids reduces the mucosal lesions caused by mesenteric ischemia compared to standard enteral nutrition, by modifying the local, but not the systemic, immune, and inflammatory response.



Keywords: Cytokines. Immunonutrition. Intestinal ischemia. N-3 fatty acids. Small bowel. Ischemic enteritis.