José L. Navarro-Olvera, Department of Functional Neurosurgery, Stereotactic and Radiosurgery, Hospital General de México, Mexico City, Mexico Gustavo Parra-Romero, Neurology and Neurosurgery Unit, General Hospital of Mexico “Dr. Eduardo Liceaga”, Mexico City, Mexico José D. Carrillo-Ruiz, Stereotactic and Radiosurgery Department, Functional Neurosurgery, Mexico General Hospital, Mexico CityCity, Mexico Gustavo Aguado-Carrillo, Stereotactic and Radiosurgery Department, Functional Neurosurgery, Mexico General Hospital, Mexico City, Mexico Julián E. Soto-Abraham, Stereotactic and Radiosurgery Department, Functional Neurosurgery, Mexico General Hospital, Mexico City, Mexico Julián E. Soto-Abraham, Stereotactic and Radiosurgery Department, Functional Neurosurgery, Mexico General Hospital, Mexico City, Mexico


Background: Stereotactic brain biopsy (SBB) is used for establishing the histological diagnosis of intracranial lesions that are not amenable for a direct surgical approach. Objective: The objective of the study was to describe our experience having an evaluation of the biopsy sample by a neuropathologist during SBB. Materials and methods: Retrospective analysis of 140 consecutive patients who underwent SBB between 2014 and 2018 in whom trans-operatory analysis of the sample was performed. Results: There were 56% men. The mean age was 45 years. Histological diagnosis was performed in 131 of 140 patients (94% overall diagnostic yield). The presurgical radiological diagnosis was correct in 39%. Neoplastic lesions were reported in 108 cases, and 32 were non-neoplastic. We performed craniotomy and resection after biopsy in 14%. We found complications in 6% of patients. Conclusions: SBB continues to be a safe, useful, and inexpensive procedure. The diagnostic performance of SBB increases when intraoperative cytological evaluation by a neuropathologist is included in the study.



Keywords: Biopsy. Brain tumor. Diagnostic yield. Histopathology. Stereotaxy.