Sergio Sobrino-Cossío, Clínica Gástrica, Hospital Ángeles del Pedregal, Ciudad de México, México
Jorge Cossío-Aranda, Departamento de Cardiología, Hospital Ángeles del Pedregal. Ciudad de México, México
Elymir Galvis-García, Servicio de Endoscopia, Hospital General de México Dr. Eduardo Liceaga, Ciudad de México, México; Clínica Gástrica, Hospital ABC Santa Fe, Ciudad de México, México
Gualberto Mateos-Pérez, Clínica Gástrica, Centro Avanzado en Endoscopia y Estudios Funcionales; Servicio de Endoscopia, Hospital Ángeles del Pedregal. Ciudad de México, México
Óscar Teramoto-Matsubara, Clínica Gástrica, Centro Avanzado en Endoscopia y Estudios Funcionales; Práctica Médica de Gastroenterología, Centro Médico ABC; Ciudad de México, México
Jesús A. González-Hermosillo, Clínica de Disautonomías, Instituto Nacional de Cardiología. Ciudad de México, México
Juan C. López-Alvarenga, Population Health & Biostatistics, School of Medicine, University of Texas, Rio Grande Valley, Edinburgh, Texas, USA
Mustafa Azizoglu, Deparment of Pediatric Surgery, Esenyurt Necmi Kadioglu State Hospital; Department of Stem Cell and Tissue Enginering, Health Sciences Institute, Istinye University. Istanbul, Turkey
José M. Remes-Troche, Instituto de Investigaciones Biológicas, Veracruz, México
Gastroesophageal reflux disease (GERD) is a complex and highly prevalent entity. Impaired gut-brain communication is associated with autonomic dysfunction. Modulation of the autonomic nervous system controls gastrointestinal functions. In GERD, a decrease in vagal tone (parasympathetic activity) and an increase in sympathetic activity with autonomic balance shifted towards the sympathetic system have been reported. Clinical questionnaires and non-invasive measurement of heart rate variability may be useful in patients with GERD to detect autonomic dysfunction. Restoration of parasympathetic system activity (mainly neuromodulation), with subsequent improvement of parasympathetic activity, will reduce the intensity of autonomic symptoms and GERD, improving quality of life.
Keywords: Autonomic nervous system; Heart rate variability; Gastroesophageal reflux disease; Autonomic disfunction